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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 497-508 doi: 10.1007/s11684-017-0572-1
Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
Keywords: genome-editing tools tumorigenic virus delivery method off-target effect virus-related carcinoma
Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU
Frontiers in Energy 2016, Volume 10, Issue 1, Pages 57-64 doi: 10.1007/s11708-015-0385-3
Keywords: steam turbine rotor thermal stress heat transfer coefficient empirical formula
Advanced purification and comprehensive utilization of yellow phosphorous off gas
Ping NING,Xiangyu WANG
Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2, Pages 181-189 doi: 10.1007/s11783-014-0698-1
Keywords: yellow phosphorous off gas purification comprehensive utilization
Typical off-design analytical performances of internal combustion engine cogeneration
Xiaohong HE, Ruixian CAI
Frontiers in Energy 2009, Volume 3, Issue 2, Pages 184-192 doi: 10.1007/s11708-009-0007-z
Keywords: internal combustion engine (ICE) cogeneration heat recovery steam generator (HRSG) off-design superheated
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1455-x
• Emissions from 53 in-use diesel-fueled off-road equipment were measured
Keywords: Off-road equipment Portable emission measurement system (PEMS) Real-world emissions Diesel engine
Construction Technology of Off-Site Precast Concrete Buildings
Ting Gong,Jian Yang,Hao Hu,Feng Xu
Frontiers of Engineering Management 2015, Volume 2, Issue 2, Pages 122-124 doi: 10.15302/J-FEM-2015039
Keywords: off-site construction precast concrete modular construction construction management building information
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
Frontiers of Engineering Management 2017, Volume 4, Issue 2, Pages 111-126 doi: 10.15302/J-FEM-2017027
Keywords: on-site maintenance petrochemical industry safety off-site maintenance system
Jian LU,Paul S. WILLS,P. CHRIS WILSON
Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3, Pages 477-481 doi: 10.1007/s11783-015-0820-z
Keywords: off-flavor/odor compounds liquid-liquid microextraction gas chromatography-tandem mass spectrometry
Can energy storage make off-grid photovoltaic hydrogen production system more economical?
Frontiers of Engineering Management Pages 672-694 doi: 10.1007/s42524-022-0245-x
Keywords: hydrogen off-grid photovoltaic energy storage LCOH engineering economics
Multi-target combinatory strategy to overcome tumor immune escape
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5
Keywords: immune checkpoints multi-target immune escape immune-related adverse events combination therapy
Atypical pituitary hormone–target tissue axis
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 1-17 doi: 10.1007/s11684-022-0973-7
Keywords: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP
Frontiers in Energy 2015, Volume 9, Issue 2, Pages 231-237 doi: 10.1007/s11708-015-0358-6
Keywords: non-intrusive appliance load monitoring event detection goodness-of-fit (GOF) K-means clustering ON-OFF
Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 52-60 doi: 10.1007/s11684-016-0433-3
Keywords: PPM1D hepatocellular carcinoma prognosis target therapy
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 11, Pages 985-994 doi: 10.1631/FITEE.1500149
Keywords: Maneuvering target tracking Prolonged smooth regions Variable rate model Maneuver detection
Dan WU, Chunyan ZHANG, Li HAO, Changjun GENG, Xie QUAN,
Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 4, Pages 483-491 doi: 10.1007/s11783-009-0144-y
Keywords: biodegradation volatile organic compounds (VOCs) biofiltration biofilter
Title Author Date Type Operation
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
Journal Article
Effect of heat transfer coefficient of steam turbine rotor on thermal stress field under off-design condition
Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU
Journal Article
Advanced purification and comprehensive utilization of yellow phosphorous off gas
Ping NING,Xiangyu WANG
Journal Article
Typical off-design analytical performances of internal combustion engine cogeneration
Xiaohong HE, Ruixian CAI
Journal Article
Quantification of emission variability for off-road equipment in China based on real-world measurements
Journal Article
Construction Technology of Off-Site Precast Concrete Buildings
Ting Gong,Jian Yang,Hao Hu,Feng Xu
Journal Article
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
Journal Article
Trace analysis of off-flavor/odor compounds in water using liquid-liquid microextraction coupled with
Jian LU,Paul S. WILLS,P. CHRIS WILSON
Journal Article
Can energy storage make off-grid photovoltaic hydrogen production system more economical?
Journal Article
A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load
Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP
Journal Article
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen
Journal Article
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
Journal Article